Volume 18, Issue 3 (10-2022)                   J Health Syst Res 2022, 18(3): 170-185 | Back to browse issues page

‎ 10.48305/jhsr.v18i3.1461
Research code: 0

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Introduction and Review of Liquid-Liquid Microextraction Method, Development and Applications in Sample Preparation and Extraction
Sara Karimi-Zeverdegani1 , Samane Khorshidikia2 , Zohreh Mohebian2
1- Associate Professor, Department of Occupational Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
2- PhD Student, Student Research Committee AND Department of Occupational Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract:   (4017 Views)
Dispersive liquid-liquid microextraction (DLLME) is a novel sample-preparation technique that provides high enrichment factors from the low volume of aqueous samples. This method has gained wide acceptance due to several advantages, including being inexpensive, fast, easy to develop, easy to operate with a high enrichment factor, and consuming low volume of organic solvent, which has made it available to almost all analytical laboratories. This review focuses on the improvements that have been made in the DLLME since its introduction in 2006. In this study, the use of DLLME with simultaneous derivatization of analytes, the combination of DLLME with other sample preparation techniques, and the replacement of toxic chlorinated solvents with low toxicity hydrocarbons, alcohols, and ionic liquids were described. Moreover, this paper seeks to describe the use of DLLME to pre-concentrate metal ions and further modifications of this newly developed technique. It briefly describes the various applications of DLLME for several groups of analytes, including pesticides, drugs, phenols, and other compounds, and finally, some limitations and future trends are anticipated.
Keywords: Liquid-liquid extraction, Sample preparation, Water
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Type of Study: Research | Subject: Occupational health engineering and occupational safety
Received: 2022/01/11 | Accepted: 2022/08/17 | Published: 2022/10/7
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