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Background: The live oil- rich diet may decrease the risk of cardiovascular disease through declining plasma lipid profiles as a source of MUFA. The purpose of this study was to assess the effects of olive oil- rich diet on plasma lipids and glucose levels in overweight women.   Methods: This cross-section randomized clinical trial was performed among 20 healthy overweight (BMI=25-29.9 kg/m2) women aged between 20 and 50 years old. Subjects were randomly assigned to receive a usual energy-restricted diet (-500 kcal) [51% carbohydrate, 15% protein, 34% fat, 16% SFA, 10% PUFA, 8% MUFA] or an olive oil-rich energy restricted diet [51% carbohydrate, 15% protein, 34% fat, 8% SFA, 10% PUFA, 16% MUFA]. All participants followed the diet for six weeks. Two weeks wash-out period was done before following the phase 2 diets. After completing the first phase, subjects changed their diet to the one not used in the first phase. At the beginning and the end of each phase, fasting plasma glucose and lipid levels were measured.           Findings: Both diets instructions resulted in a reduction of plasma lipid and glucose levels. Reductions by the olive oil-rich diet were greater than that by the usual diet; however, there was not any significant difference.                                                                                                                                  Conclusion: Using the olive oil-rich diet is led to a non-significant reduction in the plasma lipids, cholesterol, triglyceride, LDL, HDL comparing to the usual diet.              

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