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Background: Nurses are always faced with workload and lack of human resources and on the other hand they must play their family roles as well. According to needs of coordination between work and family tasks, this may have some effects on quality of life. This study aimed to assess work and family conflicts and its association with quality of life (QoL) among clinical nurses. Methods: This was a cross-sectional study with simple randomization which was conducted on 60 nurses who worked in three university hospitals of Tehran. The study tools included demographic information, Carlson__AWT_QUOTE__s Work-Family Conflict Scale and 36-Item Short Form Health Survey (SF-36). The significant level was set at 0.05. Findings: Result of the study revealed that work conflict with family was more than family conflict with work which time and role conflicts were more significant domains. Furthermore, these two variables had significant, linear and direct association to each other (r = 0.388; P < 0.001).Quality of life of many nurses was moderate. QoL had a significant and indirect association with work conflict with family (r = -0.469; P < 0.001) and family conflict with work (r = -0.282; P < 0.005). Conclusion: It seems that some strategies must be performed to decrease the work-family conflicts in workplace among clinical nurses.

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