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Background: Using complementary and alternative medicine (CAM) has been increased worldwide during last years and women are the greatest users of these methods especially in the pregnancy period. Due to lack of adequate information, this study aimed to assess the status of using complementary and alternative medicine by women in the pregnancy periodMethods: In this cross-sectional study, 599 women referred to the health care centers of Isfahan city, Iran, in 2013 were enrolled. Data were collected using researcher-made questionnaire that included two parts of demographic data and questions about the use of different methods of complementary and alternative medicine. Data were analyzed using independent t, Pearson and Spearman statistical tests via SPSS software).Findings: 33.2% of participants had used no method, 45.8% at least one method and 21% more than one method of complementary and alternative medicine. There was not any statistical relationship between the age and frequency of used methods. However, there was a statistical relationship between the educational and job status and the frequency of used methods.Conclusion: Considering the high frequency using complementary and alternative medicine methods by pregnant women, more future researches are recommended to be done; moreover, training of the health care providers and the community about these methods in pregnancy period is recommended, too.