Journal of Health System Research
مجله تحقیقات نظام سلامت
J Health Syst Res
Medical Sciences
http://hsr.mui.ac.ir
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ارتباط منابع رژیمی پروتئینهای گیاهی با علایم میگرن: یک مطالعه مورد- شاهدی در بین بزرگسالان ایرانی
The Association between Plant Protein Sources and Migraine Symptoms: A Case-Control Study among Iranian Adults
علوم تغذیه و صنایع غذایی
Nutrition sciences and food industry
پژوهشي
Research
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">مقدمه:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> میگرن با حملات مکرر سردردهای ناتوانکننده و اغلب با اختلالات حسی و حرکتی مشخص میشود. اگرچه تظاهرات بالینی این بیماری تحت تأثیر رژیم غذایی قرار دارد، با این حال ارتباط گروههای غذایی از جمله حبوبات و مغزیجات با میگرن شناسایی نشده است. پژوهش حاضر با هدف مقایسه مصرف حبوبات و مغزیجات در بیماران مبتلا به میگرن و افراد سالم و بررسی ارتباط مصرف آنها با میگرن انجام شد.</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">روشها: </span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">در این مطالعه،</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> 140 بیمار مبتلا به میگرن و 230 فرد سالم همسانسازی شده از نظر سنی شرکت کردند. دریافتهای غذایی با استفاده از پرسشنامه نیمه کمی بسامد خوراکی </span></span></span></span></span></span></span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">(</span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Food Frequency Questionnaire</span></span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> یا </span></span></span><span style="font-size:10.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">FFQ</span></span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">)</span></span></span><span style="font-size:11pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> مورد ارزیابی قرار گرفت. ویژگیهای سردردهای میگرنی و نتیجه سردرد روزانه (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Headache daily result</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> یا </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">HDR</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">) نیز با استفاده از مقیاس آنالوگ دیداری (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Visual analogue scale</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> یا </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">VAS</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">) بررسی گردید.</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">یافتهها:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> یافتهها حاکی از مصرف کمتر حبوبات و نه مغزیجات در بیماران بود. پس از کنترل عوامل مخدوشکننده بالقوه، بیماران در بالاترین سهک مصرف حبوبات، 9/2 برابر احتمال میگرن شدیدتر </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">[</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">16/8-03/1 = </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Confidence interval</span></span></span><span style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">CI</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">) 95 درصد، 35/0 = </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Odds ratio</span></span></span><span style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">OR</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">] </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">و</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> 65 درصد احتمال کمتری برای تکرر حملات میگرن داشتند (97/0-13/0 = </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">CI</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> 95 درصد، 35/0 = </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">OR</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">). مصرف بالاتر مغزیجات نیز با 63 درصد احتمال کمتر بروز سردردهای طولانی مدت </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">(</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">99/0-14/0 = </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">CI</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> 95 درصد، 37/0 = </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">OR</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">) و 69 درصد احتمال کمتر </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">HDR</span></span></span><span style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"> در بیماران همراه بود</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">.</span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">نتیجهگیری</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:">: نتایج به دست آمده نشان دهنده ارتباط مصرف حبوبات با شدت بیشتر و دفعات کمتر حملات میگرنی میباشد.</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:115%"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span></span></div>
<div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:normal"><b>Background:</b> Migraine is characterized by frequent attacks of debilitating headaches, often accompanied by sensory and motor disturbances. Although the clinical manifestations of migraine are influenced by diet, the relationship between food groups such as legumes and nuts with migraine has not been identified. The present study was conducted to compare the consumption of legumes and nuts among patients with migraine and healthy individuals and to investigate the relationship between their consumption and migraine.</span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><b>Methods:</b> This study included 140 patients with migraine and 230 age-matched healthy individuals. Food intake was assessed using a semi-quantitative food frequency questionnaire (FFQ). The characteristics of migraine headaches and the headache daily result (HDR) were also evaluated using the visual analogue scale (VAS).</span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><b>Findings:</b> Patients with migraine consumed fewer legumes, not nuts. After adjusting for potential confounders, patients with the highest tertile legume intake were found to have a 2.9 times higher risk of severe migraines [odds ratio (OR): 2.90, 95% confidence interval (CI): 1.03-8.16] and a 65% reduced chance of experiencing recurrent migraines (OR: 0.35, 95% CI: 0.13-0.97). Patients who consumed more nuts had a 63% reduced likelihood of experiencing long-term headaches (OR: 0.37, 95% CI: 0.14-0.99) and a 69% reduced risk of HDR.</span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><b>Conclusion:</b> Our findings indicated that higher consumption of legumes was associated with increased intensity and decreased frequency of migraine attacks.</span></span></span></div>
حبوبات, پروتئینهای گیاهی, میگرن, بزرگسال
Legumes, Plant proteins, Migraine, Adult
160
168
http://hsr.mui.ac.ir/browse.php?a_code=A-10-745-2&slc_lang=fa&sid=1
Fatemeh
Navab
فاطمه
نواب
f.navab.99@gmail.com