Journal of Health System Research
مجله تحقیقات نظام سلامت
J Health Syst Res
Medical Sciences
http://hsr.mui.ac.ir
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پتانسیل التهابی رژیم غذایی مبتنی بر غذا و سرطان پستان: یک مطالعه مورد شاهدی
Food-Based Inflammatory Potential of Diet and Breast Cancer: A Case-Control Study
علوم تغذیه و صنایع غذایی
Nutrition sciences and food industry
كاربردي
Applicable
<div style="text-align: justify;"><span style="font-size:14px;"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">مقدمه:</span></span></span></b><b> </b><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">سرطان پستان یکی از سرطانهای شایع در بین زنان میباشد. مطالعات پیشین به بررسی ارتباط بین شاخص التهابی رژیم غذایی مبتنی بر غذا (</span></span></span><span dir="LTR"><span new="" roman="" style="font-family:" times=""><span style="color:black">FDII</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"> یا </span></span></span><span dir="LTR"><span new="" roman="" style="font-family:" times=""><span style="color:black">Food-based dietary inflammatory index</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">) و سرطان پستان نپرداختهاند. بنابراین، پژوهش حاضر با هدف بررسی ارتباط بین </span></span></span><span dir="LTR"><span new="" roman="" style="font-family:" times=""><span style="color:black">FDII</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"> و سرطان پستان در زنان ایرانی انجام شد.</span></span></span><b><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></b></span></span></span></span><br>
<span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">روشها</span></span></span></b><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">: </span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">در این مطالعه مورد- شاهدی مبتنی بر جمعیت، دریافتهای غذایی 350 بیمار مبتلا به سرطان پستان تازه تشخیص مورد تأیید پاتولوژیست و 700 شاهد از طریق تکمیل پرسشنامه بسامد خوراک نیمه کمی 106 آیتمی (</span></span></span><span dir="LTR"><span new="" roman="" style="font-family:" times=""><span style="color:black">Food frequency questionnaire</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"> یا </span></span></span><span dir="LTR"><span new="" roman="" style="font-family:" times=""><span style="color:black">FFQ</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">) جمعآوری و شاخص </span></span></span><span dir="LTR"><span new="" roman="" style="font-family:" times=""><span style="color:black">FDII</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"> بر اساس دریافتهای غذایی شرکتکنندگان محاسبه گردید. همچنین، با استفاده از یک پرسشنامه از پیش آزمایش شده، اطلاعاتی در مورد متغیرهای مخدوشگر احتمالی جمعآوری شد</span></span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">.</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span></span><br>
<span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">یافتهها:</span></span></span></b><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"> میانگین امتیاز شاخص </span></span></span><span dir="LTR"><span new="" roman="" style="font-family:" times=""><span style="color:black">FDII</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"> از 19/4 تا 01/34- متغیر بود. ارتباط مستقیم و معنیداری بین شاخص </span></span></span><span dir="LTR"><span new="" roman="" style="font-family:" times=""><span style="color:black">FDII</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"> و سرطان پستان یافت شد؛ به طوری که پس از تعدیل تأثیر مخدوشکنندههای احتمالی، زنانی که در بالاترین سهک امتیاز شاخص </span></span></span><span dir="LTR"><span new="" roman="" style="font-family:" times=""><span style="color:black">FDII</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"> قرار داشتند در مقایسه با زنانی که در پایینترین سهک قرار داشتند، 52 درصد شانس بیشتری را برای ابتلا به سرطان پستان نشان دادند (نسبت شانس: 52/1، 95 درصد فاصله اطمینان: 18/2-05/1). چنین رابطه مستقیمی برای زنانی که در دوران یائسگی بودند، چه قبل از تعدیل متغیرهای مخدوشگر (نسبت شانس: 53/1، 95 درصد فاصله اطمینان: 14/2-09/1) و چه بعد از تعدیل متغیرهای مخدوشگر (نسبت شانس: 54/1، 95 درصد فاصله اطمینان: 27/2-05/1) مشاهده گردید. همچنین، ارتباط مستقیمی برای زنان با وزن طبیعی حتی بعد از تعدیل متغیرهای مخدوشگر نیز مشاهده شد (نسبت شانس: 58/1، 95 درصد فاصله اطمینان: 41/2-04/1).</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span></span><br>
<span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span sans-serif="" style="font-family:Calibri,"><b><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">نتیجهگیری:</span></span></span></b><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"> رابطه مستقیمی بین شاخص </span></span></span><span dir="LTR"><span new="" roman="" style="font-family:" times=""><span style="color:black">FDII</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"> و شانس ابتلا به سرطان پستان به ویژه در بین زنانی که در دوران یائسگی قرار دارند، وجود دارد. تحقیقات آیندهنگر بیشتری به منظور بررسی این ارتباط مورد نیاز میباشد.</span></span></span><span dir="LTR"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:107%"><span sans-serif="" style="font-family:Calibri,"><span style="color:black"></span></span></span></span></div>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Background</span></span></span></b><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">:</span></span></span></b> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Breast cancer is one of the most common cancers among women. There is no study on the association of food-based dietary inflammatory index (FDII) and the odds of breast cancer. This study was conducted to investigate the association between FDII and the odds of breast cancer in Iranian women</span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">.</span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Methods:</span></span></span></b> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">In this population-based case-control study, dietary intakes of 350 pathologically confirmed new cases of breast cancer and 700 controls were collected by completing a 106-item semi-quantitative food frequency questionnaire (FFQ). The FDII score was calculated based on participants’ dietary intakes. Data on potential confounding variables were also collected using a pre-tested questionnaire.</span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Findings:</span></span></span></b> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">The mean FDII score ranged from -34.01 to 4.19. A significant positive association was found between FDII and the odds of breast cancer, such that after taking potential confounders into account, women in the highest tertile of FDII score were 1.52 times more likely to have breast cancer compared with those in the lowest tertile [odds ratio (OR): 1.52, 95% confidence interval (CI): 1.05-2.18]. Such a</span></span></span><span lang="EN-GB" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> significant positive association was also observed among postmenopausal women, either before </span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">(OR: 1.53, 95% CI: 1.09-2.14) or after (OR: 1.54, 95% CI: 1.05-2.27) controlling for </span></span></span><span lang="EN-GB" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">confounding variables. The same association was also seen in normal-weight women,</span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> and it remained significant even after controlling for potential confounders (OR: 1.58, 95% CI: 1.04-2.41).</span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion:</span></span></span></b> <span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">We found a significant positive association between FDII and the odds of breast cancer in women, particularly </span></span></span><span lang="EN-GB" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">postmenopausal ones. </span></span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Prospective studies are needed to examine this relationship further.</span></span></span></span></span></span></span></span></div>
شاخص التهابی رژیم غذایی مبتنی بر غذا, رژیم غذایی, سرطان پستان, مطالعات مورد- شاهدی
Food-based dietary inflammatory index, Diet, Breast cancer, Case-control studies
489
497
http://hsr.mui.ac.ir/browse.php?a_code=A-10-837-1&slc_lang=fa&sid=1
Niloofar
Eshaghian
نیلوفر
اسحاقیان
eshaghian.niloofar@gmail.com