Volume 14, Issue 3 (10-2018)
J Health Syst Res 2018, 14(3): 279-284 |
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Ordudari Z, Rismanchian M, Ebrahimpour K. Is There a Simpler, Rapider, and More Economical Method for Extracting trans,trans-Muconic Acid (T,T-MA) as Benzene Metabolite?. J Health Syst Res 2018; 14 (3) :279-284
URL: http://hsr.mui.ac.ir/article-1-1052-en.html
URL: http://hsr.mui.ac.ir/article-1-1052-en.html
1- MSc Student, Student Research Committee AND Department of Occupational Health Engineering , School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
2- Assistant Professor, Department of Occupational Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
3- Assistant Professor, Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
2- Assistant Professor, Department of Occupational Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
3- Assistant Professor, Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract: (1130 Views)
Background: Among aromatic hydrocarbons, exposure to benzene, as a known carcinogen, has the highest health risk. trans,trans-muconic acid (tt-MA) is a non-toxic product of benzene metabolism. This study aimed to select a simple, rapid, and more economical method for determination of t,t-MA.Methods: This study reviewed some reported methods for extraction of t,t-MA from urine samples in order to propose the most cost-effective one.Findings: After reviewing some related literatures, four methods solid-phase extraction (SPE), liquid-liquid extraction (LLE), molecularly imprinted solid-phase extraction (MISPE), and molecular-imprinted polymer/dispersive liquid-liquid micro-extraction (MIP-DLLME) were found for extraction of t,t-MA.Conclusion: After surveying the advantages and disadvantages of the mentioned methods, it was found that the PDLLME method can be considered as one of the most appropriate methods for detecting t,t-MA in the urine samples, due to its high recovery and easy application.
Type of Study: Research |
Subject:
education health and promotion
Received: 2020/07/16 | Accepted: 2018/10/15 | Published: 2018/10/15
Received: 2020/07/16 | Accepted: 2018/10/15 | Published: 2018/10/15
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