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Background: Soy milk replacement in the diet may have beneficial effects on anthropometric and blood pressure values in overweight and obese individuals. Therefore, in this study the effects of soy milk replacements on the weight, waist circumference and blood pressure are examined among overweight and obese youth females. Methods: This was a cross-over randomized clinical trial on 23 overweight and obese female subjects. All patients were on a weight reducing diet. There were two trial periods for six weeks (soy milk period and caw__AWT_QUOTE__s milk period) and a washout period for 3 weeks. In the soy milk period only one glass of soy milk (240 cc) was replaced by one glass of caw__AWT_QUOTE__s milk (240 cc). Findings: The mean age of the patients was 22 ± 2 years. The mean BMI was 28.1 ± 0.5 kg/m2. Weight and waist circumference did not changed significantly after soy milk period compared to the caw__AWT_QUOTE__s milk period (mean percentage change in soy milk period for weight: -3.6±0.4 vs -2.2±0.3 in the caw__AWT_QUOTE__s milk period; P=0.82 and for waist: -0.8±0.2 vs -1.0±0.2; P=0.11). The systolic blood pressure reduced significantly following the soy milk period (mean percentage change in soy milk period: -4.0±0.9 vs -1.7±0.5 in the caw__AWT_QUOTE__s milk period; P< 0.05). The diastolic blood pressure also reduced in the soy milk period (-0.4 ±0.1 vs 0.4±0.1; P< 0.05). Conclusion: Soy milk replacement could reduce both systolic and diastolic blood pressure among overweight and obese youth females. However, this replacement had no significant results on the weight and the waist circumference.  Key Words: Soy Milk, Female Youths, BMI, Weight, Overweight, Obesity

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