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Background: Coronary artery patients had a much anxiety and distress in the acute situation that this stress leads to more ischemia, re-infarction, tachycardia and ventricular fibrillation. On the other hand heart disease affects person's spirituality. Although findings of numerous studies revealed significant relation between spiritual well-being and stress in cardiac patients, but paradoxical findings in researches encouraged us to design and perform study of the relationship between spiritual well-being and stress in patients with coronary artery disease. Methods: In this descriptive – correlation study, 392 patients with coronary artery disease admitted in special section were enrolled with census method in 6 months. Finally 85 patients with inclusion criteria filled the questionnaire (demographic information, spiritual well-being scale and situational spielberger questionnaire). Data was analyzed in SPSS-18 and by using descriptive methods as well as spearman and pearson's correlation coefficients. In present study P-value < 0.05 was significant. Findings: Mean total score of spiritual well-being was 103.11 ± 9.68 from 120, mean score of existential aspect of spiritual well-being was 45.48± 9.06 from 60 and mean scores of religious aspect was 57.63± 4.20 from 60. Also mean scores of situational anxiety was 40.80± 13.03. There was statistically significant relationship between anxiety and existential (P < 0.001; r = -0.46) and religious (P = 0.01; r = -0.26) aspects of spiritual well-being in patients with heart ischemic disease. Anxiety and total score of spiritual well-being were also significantly (P < 0.001; r = -0.47). Conclusion: This study strongly indicate that coronary arteries patients with higher scores spirituality well being had less anxiety. So spirituality well being was a protective factor against anxiety in these patients.  

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