Volume 20, Issue 3 (10-2024)
J Health Syst Res 2024, 20(3): 267-272 |
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Research code: 3400834
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Pourjam-Alavijeh Z, Rismanchian M, Mohammadalipour A, Karimi-Zeverdegani S. Investigating the Oxidative Stress in Lung Tissue of Male Wistar Rats Exposed to Welding Fumes. J Health Syst Res 2024; 20 (3) :267-272
URL: http://hsr.mui.ac.ir/article-1-1688-en.html
URL: http://hsr.mui.ac.ir/article-1-1688-en.html
1- MSc Student, Student Research Committee AND Department of Occupational Health and Safety Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
2- Associate Professor, Department of Occupational Health and Safety Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
3- Assisstant Professor, Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2- Associate Professor, Department of Occupational Health and Safety Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
3- Assisstant Professor, Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract: (448 Views)
Background: Welding is a common industrial process that impacts the health status of many workers around the world. The objective of this study was to examine the impact of welding fumes on the levels of antioxidant enzymes, which play a crucial role in lung pathogenesis.
Methods: This cross-sectional and experimental research involved producing welding fumes by performing the welding process on a steel piece within a chamber. A personal sampler pump was used to sample the welding fumes, and the filters were analyzed using an inductively coupled plasma-optical emission spectroscopy (ICP-OES) device. In this study, rats were divided into two groups: case and control (each group contained 6 rats). The case group was exposed to fumes for 30 minute/day × 8 days. After the exposure period, their lung tissue was examined using biological kits, and the levels of antioxidant enzymes [glutathione peroxidase (GPx) and superoxide dismutase (SOD)] were measured.
Findings: The concentrations of lead (Pb), chromium (Cr), aluminum (Al), copper (Cu), manganese (Mn), and iron (Fe) were 0.131, 0.084, 0.100, 0.019, 2.25, and 12.06 mg/m3, respectively. The average activity of GPx in the control and exposure groups was 16.3438 (mU/mg protein) and 11.81042 (mU/mg protein), respectively. The average activity of SOD in the control and exposure groups was 275.587 (U/mg protein) and 121.168 (U/mg protein), respectively.
Conclusion: According to obtained data, welding fumes have a significant effect on reducing the activity of antioxidant enzymes and causing mild to severe damage to lung tissue.
Methods: This cross-sectional and experimental research involved producing welding fumes by performing the welding process on a steel piece within a chamber. A personal sampler pump was used to sample the welding fumes, and the filters were analyzed using an inductively coupled plasma-optical emission spectroscopy (ICP-OES) device. In this study, rats were divided into two groups: case and control (each group contained 6 rats). The case group was exposed to fumes for 30 minute/day × 8 days. After the exposure period, their lung tissue was examined using biological kits, and the levels of antioxidant enzymes [glutathione peroxidase (GPx) and superoxide dismutase (SOD)] were measured.
Findings: The concentrations of lead (Pb), chromium (Cr), aluminum (Al), copper (Cu), manganese (Mn), and iron (Fe) were 0.131, 0.084, 0.100, 0.019, 2.25, and 12.06 mg/m3, respectively. The average activity of GPx in the control and exposure groups was 16.3438 (mU/mg protein) and 11.81042 (mU/mg protein), respectively. The average activity of SOD in the control and exposure groups was 275.587 (U/mg protein) and 121.168 (U/mg protein), respectively.
Conclusion: According to obtained data, welding fumes have a significant effect on reducing the activity of antioxidant enzymes and causing mild to severe damage to lung tissue.
Keywords: Welding, Lung injury, Oxidative stress, Superoxide dismutase, Glutathione peroxidase, Rats
Type of Study: Research |
Subject:
Occupational health engineering and occupational safety
Received: 2023/11/18 | Accepted: 2023/12/16 | Published: 2024/10/6
Received: 2023/11/18 | Accepted: 2023/12/16 | Published: 2024/10/6
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